Telomerase Expression Related with Poor Immune Response to HCV Core Antigen in Egyptian HCV Patients’ PBMCs
نویسندگان
چکیده
IntroductionHepatocellular carcinoma (HCC) is the most common primary malignant tumor of liver.AimThis study aimed to assess serum hTERT level and its relation progression liver disease. Also, it effect HCV core protein on memory T-cells in patients with or without HCC, correlation between cells phenotype disease same patients.MethodsHTERT was assessed through relative quantitative RT-PCR. Flow cytometric analysis used responsiveness (as IFN-γ secretion) before after stimulation protein, CD8+ using several differentiation markers.ResultsHTERT found be increased a stepwise manner upon comparing controls, chronic hepatitis patients, cirrhotic HCC patients. showed similar decrease response (decreased compared controls. late differentiated (CD8+ CD27- CD28- CD45RA+CCR7-) were depleted HCC.ConclusionThese results suggest negative secretion by T- that this relationship along depletion could help HCC.
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ژورنال
عنوان ژورنال: Journal of clinical and experimental hepatology
سال: 2023
ISSN: ['0973-6883', '2213-3453']
DOI: https://doi.org/10.1016/j.jceh.2023.06.004